Adding cagrilintide to tirzepatide Theoretical protocol (not clinically studied): If on tirzepatide 10-15mg: Stable on tirzepatide for 4+ weeks Continue tirzepatide at current dose Add cagrilintide 0.6mg weekly Standard cagrilintide titration to 2.4mg Rationale: Tirzepatide is dual GIP/GLP-1 (very powerful alone) Adding amylin pathway could theoretically enhance No clinical data on this combination Uncertain if additional benefit over tirzepatide alone Concerns: GI side effects may be severe (both slow gastric emptying) Tirzepatide already produces 15-22% weight loss alone Unclear if cagrilintide adds meaningful benefit Expensive combination Verdict: Wait for clinical data
1,5 PIONEER 4, PIONEER 2, and PIONEER 3 primary endpoint: Mean change in A1C from baseline at Week 26
Nishimura M, Ohkawara T, Kanayama T, Kitagawa K, Nishimura H, Nishihira J
It can improve quality of life in so many ways, whether for joint pain, sexual wellness, skin rejuvenation, or even as a natural alternative to filler
Retatrutide achieved its results in only 48 weeks compared to Mounjaros 72-week trial